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Histamine intolerance is a presumed set of adverse reactions (such as flush, itching, rhinitis, etc.) to ingested histamine in food. The mainstream theory accepts that there may exist adverse reactions to ingested histamine, but does not recognize histamine intolerance as a separate medical condition that can be diagnosed. [1]
Mast cell activation syndrome (MCAS) is a term referring to one of two types of mast cell activation disorder (MCAD); the other type is idiopathic MCAD. [1] MCAS is an immunological condition in which mast cells, a type of white blood cell, inappropriately and excessively release chemical mediators, such as histamine, resulting in a range of chronic symptoms, sometimes including anaphylaxis or ...
Currently a Consultant in Clinical Immunology and Allergy at the Royal Free Hospital and University College London, the largest Primary Immunodeficiency Centre in Europe, Seneviratne was a Consultant and Lead Clinician in Clinical Immunology and Allergy at St Mary's Hospital and Imperial College London before, a world renowned Allergy and Immunology Centre, and the birthplace of the widely ...
During that time, many dietitians advised that a diet devoid of histamine-liberating foods was the ideal strategy to prevent symptoms of histamine intolerance from manifesting. Lists of foods deemed to be histamine-liberating were published in various scientific articles, which included fermented sausages, cured cheese, wine and beer. [11]
Dermographism can be treated by substances which prevent histamine from causing the reaction (i.e. an antihistamine). These may need to be given as a combination of H 1 antagonists, or possibly with an H 2-receptor antagonist such as cimetidine. [6] [7] Over-the-counter vitamin C, 1000 mg daily, increases histamine degradation and removal.
They block mast cell degranulation, stabilizing the cell and thereby preventing the release of histamine and related mediators. One suspected pharmacodynamic mechanism is the blocking of IgE-regulated calcium channels. Without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate. [1]
A mast cell (also known as a mastocyte or a labrocyte [1]) is a resident cell of connective tissue that contains many granules rich in histamine and heparin.Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems.
The Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) is a UK independent scientific committee that provides advice to the Food Standards Agency, the Department of Health and other government departments and agencies on matters concerning the toxicity of chemicals.