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These nerve injuries are more difficult to treat and generally have a poorer outcome. In addition, associated injuries, like injury to bone, muscle and skin, can make nerve recovery more difficult. [13] The level of injury: After a nerve is repaired, the regenerating nerve endings must grow all the way to their target. For example, a nerve ...
Nerve tissue loss is associated with the more severe nerve injuries. 50-60% of sensory and motor neurons has been calculated from experiments after the use of nerve grafts Schwann cells form myelin, insulation to the nerve to allow better conduction along the axon, around the nerve fibers and secrete growth factors that play a major role in the ...
A nerve guidance conduit (also referred to as an artificial nerve conduit or artificial nerve graft, as opposed to an autograft) is an artificial means of guiding axonal regrowth to facilitate nerve regeneration and is one of several clinical treatments for nerve injuries.
These include the sparse identification of neurons and nerve fibers, the lack of a thorough examination of fine nerve fibers, the incomplete knowledge of innervation in particular regions, and the inadequate documentation in certain studies of close interactions between immune and non-immune cells and nerve fibers.
In 2004, a study looked at how Lewis rats' sensory vs motor nerve grafts affected the regeneration of a cut mixed nerve system (both motor and sensory nerves). It was noted that after 3 weeks, a mixed nerve defect had undergone substantial regeneration when paired with a motor nerve graft or a mixed nerve graft.
In 1945, after WWII, Sir Sunderland described the anatomy of the peripheral nerves and developed techniques to improve the outcomes of nerve repair. A successful regeneration for short allografts (<4 cm) was achieved. However, there was a period of failure to accomplish successful recovery for all the allografts longer than 4 cm.
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