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This may be amplified by frequent vomiting when the cat does choose to eat. A lack of appetite causes the cat to refuse any food, even after it has purged its system of all stomach contents. Severe weight loss proceeds as the liver keeps the cat alive off body fat, causing a yellowing of the skin (jaundice).
Effect of water content in a canned food on voluntary food intake and body weight in cats. Am J Vet Res. 2011 Jul;72(7):918-23. doi: 10.2460/ajvr.72.7.918. PMID: 21728852.
First and foremost, the cat must be kept well hydrated with wet food/soups/broth/increased water intake. This keeps the urine dilute, reducing pain and inflammation, as well as encouraging urination to keep the bladder clear of debris thereby reducing the risk of a § mechanical blockage .
Clinical signs: the cat has become anorexic or is eating less than usual; has lost weight or failed to gain weight; has a fever of unknown origin; intra-ocular signs; jaundice. [18] Biochemistry: hypergammaglobulinaemia; raised bilirubin without liver enzymes being raised. Hematology: lymphopenia; non-regenerative—usually mild—anaemia.
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Feline idiopathic cystitis (FIC) is by far the most common form of FLUTD in young to middle-aged cats. It is a disease whose cause is not fully understood but is thought to be related to stress events and a cat's pre-disposition to anxiety, as well as certain lifestyle choices (e.g. a dry food diet, no access to outdoor space).