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Reproductive toxicants may adversely affect sexual function, ovarian failure, fertility as well as causing developmental toxicity in the offspring. [ 2 ] [ 3 ] Lowered effective fertility related to reproductive toxicity relates to both male and female effects alike and is reflected in decreased sperm counts, semen quality and ovarian failure.
Developmental toxicity is any developmental malformation that is caused by the toxicity of a chemical or pathogen. It is the structural or functional alteration, reversible or irreversible, which interferes with homeostasis, normal growth, differentiation, development or behavior.
Reproductive Toxicology is a peer-reviewed journal published bimonthly by Elsevier which focuses on the effects of toxic substances on the reproductive system. The journal was established in 1987 and is affiliated with the European Teratology Society. According to the Journal Citation Reports, the journal has a 2023 impact factor of 3.3. [1]
SENDIG 3.1 was released in June 2016, extending the format with new data domains. SENDIG-DART 1.1 was released in December 2017. SENDIG-DART is a standard which extends the SENDIG 3.1 standard for use with Segment II Development and Reproductive Toxicology Studies.
Environmental toxicants and fetal development is the impact of different toxic substances from the environment on the development of the fetus.This article deals with potential adverse effects of environmental toxicants on the prenatal development of both the embryo or fetus, as well as pregnancy complications.
She joined the National Institute of Environmental Health Sciences in September 2009 as a reproductive endocrinologist in the mechanistic toxicology branch. [3] She researched how per- and polyfluoroalkyl substances and other environmental chemicals affect health across the lifespan — from fetal outcomes and mammary gland development to ...
Teratology is the study of abnormalities of physiological development in organisms during their life span. It is a sub-discipline in medical genetics which focuses on the classification of congenital abnormalities in dysmorphology caused by teratogens and also in pharmacology and toxicology.
Ovarian culture is an in-vitro process that allows for the investigation of the development, toxicology and pathology of the ovary. [1] This technique can also be used to study possible applications of fertility treatments e.g. isolating oocytes from primordial ovarian follicles that could be used for fertilisation.