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However, PKM2 contains an inducible nuclear localization signal in its C-terminal domain. The role of PKM2 within the nucleus is complex, since pro-proliferative but also pro-apoptotic stimuli have been described. On the one hand, nuclear PKM2 was found to participate in the phosphorylation of histone 1 by direct phosphate transfer from PEP to ...
Some sociologists and anthropologists consider the extended family structure to be the most common family structure in most cultures and at most times, rather than the nuclear family. [1] [2] The term nuclear family was popularized in the 20th century. Since that time, the number of North American nuclear families is gradually decreasing, while ...
Nucleoporins are a family of proteins which are the constituent building blocks of the nuclear pore complex (NPC). [1] The nuclear pore complex is a massive structure embedded in the nuclear envelope at sites where the inner and outer nuclear membranes fuse, forming a gateway that regulates the flow of macromolecules between the cell nucleus and the cytoplasm.
An impressive sparkling Riesling that could fool many people into thinking it was regular sparkling wine, this German multi-vintage blend has fresh, zippy flavors and a minerally end; serve it on ...
The nuclear family consists of a mother, father, and the children. The two-parent nuclear family has become less prevalent, and pre-American and European family forms have become more common. [2] Beginning in the 1970s in the United States, the structure of the "traditional" nuclear American family began to change.
Editor’s Note: Examining clothes through the ages, Dress Codes is a new series investigating how the rules of fashion have influenced different cultural arenas — and your closet. Red velvet ...
Part 1 of the "Abbott Elementary" and "It's Always Sunny in Philadelphia" crossover aired on Wednesday, Jan. 8, at 8:30 p.m. ET/PT. The second crossover is expected later in 2025, but Season 17 of ...
The PFKFB3 promoter is predicted to contain multiple binding sites, including Sp-1 and AP-2 binding sites. It also contains motifs for the binding of E-box, nuclear factor-1 (NF-1), and progesterone response element. Expression of the promoter is shown to be induce by phorbol esters and cyclic-AMP-dependent protein kinase signaling. [10]