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The antioxidant enzyme glutathione peroxidase 4 (GPX4) belongs to the family of glutathione peroxidases, which consists of 8 known mammalian isoenzymes (GPX1–8).GPX4 catalyzes the reduction of hydrogen peroxide, organic hydroperoxides, and lipid peroxides at the expense of reduced glutathione and functions in the protection of cells against oxidative stress.
Mutations in the GSS gene prevent cells from making adequate levels of glutathione, leading to the signs and symptoms of glutathione synthetase deficiency. This disorder is inherited in an autosomal recessive pattern, which means the defective gene is located on an autosome , and two copies of the gene - one from each parent - are required to ...
Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein.The intravenous route of administration is commonly used for rehydration or to provide nutrients for those who cannot, or will not—due to reduced mental states or otherwise—consume food or water by mouth.
Glutathione peroxidase (GPx) (EC 1.11.1.9) is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage. [2] The biochemical function of glutathione peroxidase is to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to ...
More and more treatment options are becoming available for obesity and overweight. This includes type 2 diabetes drugs and weight loss medications like Ozempic® and Wegovy® (semaglutide).
69590 Ensembl ENSG00000164294 ENSMUSG00000021760 UniProt Q8TED1 Q9D7B7 RefSeq (mRNA) NM_001008397 NM_001306197 NM_001306198 NM_001306201 NM_027127 RefSeq (protein) NP_001008398 NP_001293126 NP_001293127 NP_001293130 NP_081403 Location (UCSC) Chr 5: 55.16 – 55.17 Mb Chr 13: 113.18 – 113.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Glutathione peroxidase 8 (GPx-8) is an ...