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Polysorbate 80 is a surfactant and solubilizer used in a variety of oral and topical pharmaceutical products.. Polysorbate 80 is also an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone. [9]
Polysorbate 60 (polyoxyethylene (20) sorbitan monostearate) Polysorbate 80 (polyoxyethylene (20) sorbitan monooleate) The number following the 'polysorbate' part is related to the type of major fatty acid associated with the molecule. Monolaurate is indicated by 20, monopalmitate is indicated by 40, monostearate by 60, and monooleate by 80.
polysorbate 20: emulsifier 433 A E U polysorbate 80: emulsifier 434 E U polysorbate 40: emulsifier 435 A E U polysorbate 60: emulsifier 436 A E U polysorbate 65: emulsifier 440 A E U pectin: vegetable gum, emulsifier 441 U
Docetaxel is a white powder and is the active ingredient available in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80. [16] [17] The solution is a clear brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.
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The chemical structure shown for Polysorbate 80 appears to be incorrect. Polysorbate 80 is made by polymerization of 20 equivalents of ethylene oxide with sorbitan monooleate [1]. The method of synthesis is summarized in Chapter 2 of Food Emulsifiers and Their Applications: Hasenhuettl, Gerard L., Hartel, Richard W. (Eds.) [2]. Aside from the ...
Coating these polymeric nanoparticle devices with different surfactants can also aid BBB crossing and uptake in the brain. Surfactants such as polysorbate 80, 20, 40, 60, and poloxamer 188, demonstrated positive drug delivery through the blood–brain barrier, whereas other surfactants did not yield the same results. [2]
A highly viscous cubic phase gel made of polysorbate 80, water, and liquid paraffin. Lyotropic liquid crystals result when amphiphiles, which are both hydrophobic and hydrophilic, dissolve into a solution that behaves both like a liquid and a solid crystal. This liquid crystalline mesophase includes everyday mixtures like soap and water. [1] [2]