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On 30 March 1842, he administered diethyl ether by inhalation to a man named James Venable, in order to remove a tumor from the man's neck. [102] Long later removed a second tumor from Venable, again under ether anesthesia. He went on to employ ether as a general anesthetic for limb amputations and childbirth. Long, however, did not publish his ...
Drinking ether is challenging as it boils below body temperature and is not miscible with water, requiring precautions: . There is an art in swallowing the ether. The drinker first washes out his mouth with water “to cool it;” next he swallows a little water to cool his throat; then he tosses down the glass of ether; finally, he closes in with another draught of water to keep the ether ...
Diethyl ether was found to have undesirable side effects, such as post-anesthetic nausea and vomiting. Modern anesthetic agents reduce these side effects. [27] An illustration depicting ether's effects, 1840s–1870s. Prior to 2005, it was on the World Health Organization's List of Essential Medicines for use as an anesthetic. [35] [36]
Chloroform is a much stronger and effective anaesthetic than ether, it is non-inflammable and it did not irritate the airways, unlike ether. First non-gaseous inhalational anaesthetics such as ether and chloroform were inhaled from a handkerchief which the liquid was poured on and allowed to evaporate.
General anesthesia is usually considered safe; however, there are reported cases of patients with distortion of taste and/or smell due to local anesthetics, stroke, nerve damage, or as a side effect of general anesthesia. [46] [47] At the end of surgery, administration of anaesthetic agents is discontinued.
Enflurane (2-chloro-1,1,2-trifluoroethyl difluoromethyl ether) is a halogenated ether. Developed by Ross Terrell in 1963, it was first used clinically in 1966. It was increasingly used for inhalational anesthesia during the 1970s and 1980s [2] but is no longer in common use. [3] Enflurane is a structural isomer of isoflurane. It vaporizes ...
Since 1982, ether is not used in the United States. [7] Now, because of the use of intravenous induction agents with muscle relaxants and the discontinuation of ether, elements of Guedel's classification have been superseded by depth of anaesthesia monitoring devices such as the BIS monitor; [5] however, the use of BIS monitoring remains ...
The effects of early-life exposures to anesthesia on the brain in humans are controversial. Evidence from nonhuman primate research suggests significant developmental neurotoxicity and long-term social impairment, with a dose–response relationship where repeated exposures cause a more severe impact than single ones.