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A sterile version is used for making solutions that will be given by injection. [2] Before such use other substances generally must be added to make the solution isotonic . [ 3 ] Isotonic solutions containing water for injection can be given by injection into a vein , muscle , or under the skin . [ 4 ]
However, when the product is reconstituted in a 5% dextrose solution, it is used immediately to ensure its efficacy. [27] The degradation of meropenem in a water-based solution is affected by factors such as pH, temperature, initial concentration, and the specific type of infusion solution used. [32] Meropenem solutions should not be frozen ...
They provide the cells with water and inorganic ions, while maintaining a physiological pH and osmotic pressure. [2] Sometimes glucose is added as an energy source and phenol red is used as a pH indicator. In medicine, balanced salt solutions can be used as an irrigation solution such as during intraocular surgery and to replace intraocular fluids.
Pentamidine isethionate for injection is commercially available as a lyophilized, white crystalline powder for reconstitution with sterile water or 5% Dextrose. After reconstitution, the mixture should be free from discoloration and precipitation. Reconstitution with sodium chloride should be avoided due to formation of precipitates.
The lyophilized product is stable for extended periods of time and could allow storage at higher temperatures. In protein formulations, stabilizers are added to replace the water and preserve the structure of the molecule. [5] Before administration, a lyophilized drug is reconstituted as a liquid before being administered.
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JC Olivera/Variety via Getty. James Kennedy at DirecTV's Christmas at Kathy's at the Hiltons' private residence on December 10, 2024 in Los Angeles, California.