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Interleukin 7 (IL-7) is a protein [5] that in humans is encoded by the IL7 gene. [6] [7] [8] IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, [9] dendritic cells, [10] hepatocytes, [11] neurons, and epithelial cells, [12] but is not produced by normal ...
The receptors can both bind all three forms of IL-1 (IL-1 alpha, IL-1 beta and IL-1 receptor antagonist). The crystal structures of IL1A and IL1B [ 9 ] have been solved, showing them to share the same 12-stranded beta-sheet structure as both the heparin binding growth factors and the Kunitz-type soybean trypsin inhibitors. [ 10 ]
The IL-5 receptor is composed of an α and a βc chain. [23] The α subunit is specific for the IL-5 molecule, whereas the βc subunit also recognised by interleukin 3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF). [23] [24] Glycosylation of the Asn196 residue of the Rα subunit appears to be essential for binding of IL-5 ...
The interleukin-5 receptor is a type I cytokine receptor.It is a heterodimer of the interleukin 5 receptor alpha subunit and CSF2RB. [1] [2]The IL-5 receptor (IL-5R) belongs to the type I cytokine receptor family and is a heterodimer composed of two polypeptide chains, one α subunit, which binds IL-5 and confers upon the receptor cytokine specificity, and one β subunit, which contains the ...
The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer , and consists of two subunits, interleukin-7 receptor-α ( CD127 ) and common-γ chain receptor ( CD132 ).
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116849 Ensembl ENSG00000127318 ENSMUSG00000090461 UniProt Q9GZX6 Q9JJY8 RefSeq (mRNA) NM_020525 NM_054079 RefSeq (protein) NP_065386 NP_473420 Location (UCSC) Chr 12: 68.25 – 68.25 Mb Chr 10: 118.13 – 118.13 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin-22 (IL-22) is a protein that in humans is encoded by the IL22 gene. Structure IL-22 is an α-helical cytokine. IL ...