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Asthma is a common long-term inflammatory disease of the airways of the lungs. [4] Asthma occurs when allergens, pollen, dust, or other particles, are inhaled into the lungs, causing the bronchioles to constrict and produce mucus, which then restricts oxygen flow to the alveoli.
Inhaled short-acting β2-adrenergic agonists, such as terbutaline and salbutamol, are the first-line drugs indicated for asthma exacerbation for all patients to provide rapid bronchodilating effects. [1] [2] Short-acting β2-adrenergic agonists can be delivered by different devices, for example, nebulizers and metered-dose inhalers. [2]
The mechanisms behind allergic asthma—i.e., asthma resulting from an immune response to inhaled allergens—are the best understood of the causal factors. In both people with asthma and people who are free of the disease, inhaled allergens that find their way to the inner airways are ingested by a type of cell known as antigen-presenting ...
Terbutaline is used as a fast-acting bronchodilator (often used as a short-term asthma treatment) and as a tocolytic [6] to delay premature labor.. As an asthma treatment, the inhaled form of terbutaline, starts working within 15 minutes and can last up to 6 hours.
Short- term use of glucocorticoids creates minor disturbance in human body. The examples of short- term effects created by glucocorticoids are hyperglycemia, oscillation in blood pressure, psychiatric events and electrolyte disorders. [21] These effects usually can be reversed once the glucocorticoids therapy is stopped. [20]
In children the short term use of steroids by mouth increases the risk of vomiting, behavioral changes, and sleeping problems. [41] Dysphonia: Inhaled corticosteroids are used for treatment of asthma as a standard treatment. This can cause local adverse effects like vocal cord dysfunction. [42]
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More severe effects, such as pulmonary edema, myocardial ischemia, and cardiac arrhythmia, are exceptional.) [6] [7] [1] Overuse of β 2 agonists and asthma treatment without proper inhaled corticosteroid use has been associated with an increased risk of asthma exacerbations and asthma-related hospitalizations. [8]
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