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Deoxycytidine kinase (dCK) is an enzyme which is encoded by the DCK gene in humans. [ 5 ] dCK predominantly phosphorylates deoxycytidine (dC) and converts dC into deoxycytidine monophosphate .
(d)CMP kinase (EC 2.7.4.25, prokaryotic cytidylate kinase, deoxycytidylate kinase, dCMP kinase, deoxycytidine monophosphokinase) is an enzyme with systematic name ATP:(d)CMP phosphotransferase. [ 1 ] [ 2 ] This enzyme catalyses the following chemical reaction
Thymidylate kinase can phosphorylate TMP into thymidine diphosphate, which nucleoside diphosphate kinase can phosphorylate into thymidine triphosphate. The nucleosides cytidine and deoxycytidine can be salvaged along the uracil pathway by cytidine deaminase, which converts them to uridine and deoxyuridine, respectively.
This family includes deoxycytidine kinase (cytosolic) as well as the two mitochondrial enzymes deoxyguanosine kinase and thymidine kinase 2 in humans. The base specificity is generally broader than for the TK-1 family. Non-TK1 family members are widespread and found in eukaryotes as well as prokaryotes.
Deoxycytidine is a deoxyribonucleoside, a component of deoxyribonucleic acid. It is similar to the ribonucleoside cytidine , but with one hydroxyl group removed from the C2' position. Deoxycytidine can be phosphorylated at C5' of the deoxyribose by deoxycytidine kinase , converting it to deoxycytidine monophosphate (dCMP), a DNA precursor.
66588 Ensembl ENSG00000162368 ENSMUSG00000028719 UniProt P30085 Q9DBP5 RefSeq (mRNA) NM_001136140 NM_016308 NM_001366135 NM_025647 RefSeq (protein) NP_001129612 NP_057392 NP_001353064 NP_079923 Location (UCSC) Chr 1: 47.33 – 47.38 Mb Chr 4: 114.82 – 114.84 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse UMP-CMP kinase is an enzyme that in humans is encoded by the CMPK1 gene ...
In enzymology, a cytidylate kinase (EC 2.7.4.14) is an enzyme that catalyzes the chemical reaction ATP + (d)CMP ⇌ {\displaystyle \rightleftharpoons } ADP + (d)CDP Thus, the two substrates of this enzyme are ATP and dCMP , whereas its two products are ADP and dCDP .
In some cases, decreased expression or loss of expression of drug-metabolising enzymes confers resistance, as the enzymes are needed to process a drug from an inactive form to an active form. Arabinoside, a commonly used chemotherapy for leukemia and lymphomas, is converted into cytosine arabinoside triphosphate by deoxycytidine kinase ...