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  2. Loratadine - Wikipedia

    en.wikipedia.org/wiki/Loratadine

    Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies. [5] This includes allergic rhinitis (hay fever) and hives . [ 5 ] It is also available in drug combinations such as loratadine/pseudoephedrine , in which it is combined with pseudoephedrine , a nasal decongestant . [ 5 ]

  3. Desloratadine - Wikipedia

    en.wikipedia.org/wiki/Desloratadine

    Desloratadine sold under the brand name Clarinex among others, is a tricyclic H 1 inverse agonist that is used to treat allergies.It is an active metabolite of loratadine. [6]It was patented in 1984 and came into medical use in 2001. [7]

  4. Cetirizine - Wikipedia

    en.wikipedia.org/wiki/Cetirizine

    The pharmacokinetics of cetirizine have been found to increase linearly with dose across a range of 5 to 60 mg. [3] Its C max following a single dose has been found to be 257 ng/mL for 10 mg and 580 ng/mL for 20 mg. [2] Food has no effect on the bioavailability of cetirizine but has been found to delay the T max by 1.7 hours (i.e., to ...

  5. Pseudoephedrine/loratadine - Wikipedia

    en.wikipedia.org/wiki/Pseudoephedrine/loratadine

    A Clarinase Repetab tablet contains 5 mg loratadine in the tablet coating and 120 mg pseudoephedrine sulfate equally distributed between the tablet coating and the barrier-coated core. The two active components in the coating are quickly liberated; release of pseudoephedrine in the core is delayed for several hours.

  6. Therapeutic index - Wikipedia

    en.wikipedia.org/wiki/Therapeutic_index

    The maximum dose is used, rather than a lower dose, to reduce the number of test subjects (and, among other things, the cost of testing), to detect an effect that might occur only rarely. This type of analysis is also used in establishing chemical residue tolerances in foods. Maximum tolerated dose studies are also done in clinical trials.

  7. H1 antagonist - Wikipedia

    en.wikipedia.org/wiki/H1_antagonist

    They are also structurally related to the tricyclic antidepressants (and tetracyclics), explaining the H 1-antihistaminergic adverse effects of those three drug classes and also the poor tolerability profile of tricyclic H 1-antihistamines. The second-generation H 1-antihistamine loratadine was derived from compounds in this group. Promethazine