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Mott cells with Russell bodies (red arrows), compared to an almost normal plasma cell (white arrow; it has a prominent nucleolus). Plasmacytoma with abundant Russell bodies. H&E stain. Dutcher and Russell bodies. H&E stain. Russell bodies are inclusion bodies usually found in atypical plasma cells that become known as Mott cells. [1]
Plasma cells with Dutcher and Russell bodies (H&E stain, 100×, oil) Plasma cells are large lymphocytes with abundant cytoplasm and a characteristic appearance on light microscopy . They have basophilic cytoplasm and an eccentric nucleus with heterochromatin in a characteristic cartwheel or clock face arrangement.
The recent introduction of a commercial immunoassay for measurement of free light chains potentially offers an improvement in monitoring disease progression and response to treatment, particularly where the paraprotein is difficult to measure accurately by electrophoresis (for example in light chain myeloma, or where the paraprotein level is ...
As an example, consider groups of similar animals (mice, for example) under two different diet systems. The research question would be: what is the best diet? In this case, H 0 would be that there is no difference between the two diets in mice metabolism (H 0 : μ 1 = μ 2 ) and the alternative hypothesis would be that the diets have different ...
Hypersegmentation can also be seen in many other conditions but with relatively less diagnostic significance. Hypersegmentation can sometimes be difficult to assert since interobserver variation is high and segmentation may vary with race.
Is a benign dominantly inherited defect of terminal neutrophil differentiation as a result of mutations in the lamin B receptor gene. The characteristic leukocyte appearance was first reported in 1928 by Karel Pelger (1885-1931), a Dutch Hematologist, who described leukocytes with dumbbell-shaped bilobed nuclei, a reduced number of nuclear segments, and coarse clumping of the nuclear chromatin.
For example, poikilocytosis can be caused by a vitamin deficiency (e.g. vitamin B 12, folic acid), in which case the treatment is to replenish the deficient vitamin. It can be caused by a digestive disease, such as celiac disease , in which case the solution may lie in treating the underlying celiac disease so that nutrients can be properly ...
Reactive lymphocytes were originally described by W. Türk in 1907 in the peripheral blood of patients with infectious mononucleosis.Later in 1923 the features of the reactive lymphocytes were characterized in greater detail by Hal Downey and C.A. McKinlay, who also discovered the association with EBV and CMV.