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Interleukin 5 (IL5), also known as eosinophil differentiation factor (EDF), is a lineage-specific cytokine for eosinophilpoiesis. [ 17 ] [ 18 ] It regulates eosinophil growth and activation, [ 17 ] and thus plays an important role in diseases associated with increased levels of eosinophils, including asthma. [ 18 ]
Cytokines have been shown to be involved in autocrine, paracrine and endocrine signaling as immunomodulating agents. Cytokines include chemokines, interferons, interleukins, lymphokines, and tumour necrosis factors, but generally not hormones or growth factors (despite some overlap in the terminology) [citation needed].
Interleukin-1 alpha (IL-1 alpha) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is encoded by the IL1A gene. [5] [6] In general, Interleukin 1 is responsible for the production of inflammation, as well as the promotion of fever and sepsis. IL-1α inhibitors are being developed to interrupt those processes ...
Interleukin-2 (IL-2) is an interleukin, which is a type of cytokine signaling molecule forming part of the immune system.It is a 15.5–16 kDa protein [5] that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity.
IL-18 is known as a factor that induces the production of interferon gamma (IFN-γ). [29] It is a pro-inflammatory cytokine that shares similar biological effects to IL-12 and structural forms with the IL-1 family. Together with IL-12 it mediates cellular immunity. It binds to the IL-18Rα receptor.
Interleukins are another class of cytokine signaling molecules important in hemopoiesis. They were initially thought to be secreted uniquely by leukocytes and to communicate only with other leukocytes, and were named accordingly, but are now known to be produced by a variety of cells including bone marrow and endothelium.
Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. [2] They are produced by a group of T helper cell known as T helper 17 cell in response to their stimulation with IL-23. Originally, Th17 was identified in 1993 by Rouvier et al. who isolated IL17A transcript from a rodent T-cell hybridoma. [3]
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine.In humans, it is encoded by the IL6 gene. [5]In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation.