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Fluoride's suppressive effect on the thyroid is more severe when iodine is deficient, and fluoride is associated with lower levels of iodine. [clarification needed] [31] Thyroid effects in humans were associated with fluoride levels 0.05–0.13 mg/kg/day when iodine intake was adequate and 0.01–0.03 mg/kg/day when iodine intake was inadequate.
Most patients with skeletal fluorosis show side effects from the high fluoride dose such as ruptures of the stomach lining and nausea. [3] Fluoride can also damage the parathyroid glands, leading to hyperparathyroidism, the uncontrolled secretion of parathyroid hormones. These hormones regulate calcium concentration in the body.
Soluble fluoride salts, of which sodium fluoride is the most common, are toxic, and have resulted in both accidental and self-inflicted deaths from acute poisoning. [4] The lethal dose for most adult humans is estimated at 5 to 10 g (which is equivalent to 32 to 64 mg elemental fluoride per kg body weight).
The same was true for fluoride levels of less than 1.5 mg/L, which is the upper safe limit of fluoride in drinking water as established by the World Health Organization.
This latest study is particularly noteworthy as it marks the 10th consecutive NIH-funded study in humans to identify harmful effects of fluoride on children’s developing brains. These findings add to the mounting evidence, underscoring the urgent need to stop adding fluoride to water systems and stop its promotion in public health policies.
The fluoride opposition argues there has never been a double-blinded, randomized, controlled clinical trial — the gold standard of scientific research — looking at the effects of fluoride on ...
Robert F. Kennedy Jr. has called for water systems in the U.S. to remove fluoride, sparking controversy over the risks and benefits of fluoride in drinking water, as new research shows that ...
Complications may occur due to fluoride toxicity. [1] Once absorbed into blood through the skin, [1] it reacts with blood calcium and may cause cardiac arrest. Burns with areas larger than 160 cm 2 (25 square inches) have the potential to cause serious systemic toxicity from interference with blood and tissue calcium levels. [4]