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A simplified view of the cell-cycle control system.pdf; Date and time of digitizing: 12:02, 7 April 2020: File change date and time: 12:02, 7 April 2020: Software used:
The book was released DRM-free, in two different-quality PDF files. [82] On March 12, 2014, Munroe announced the book What If?: Serious Scientific Answers to Absurd Hypothetical Questions. The book was released on September 2, 2014. The book expands on the What If? blog on the xkcd website. [‡ 5] [8]
Tertiary structure of human Cdk2, determined by X-ray crystallography. Like other protein kinases, Cdk2 is composed of two lobes: a smaller amino-terminal lobe (top) that is composed primarily of beta sheet and the PSTAIRE helix, and a large carboxy-terminal lobe (bottom) that is primarily made up of alpha helices.
Cyclin binding alone causes partial activation of Cdks, but complete activation also requires activating phosphorylation by CAK. In animal cells, CAK phosphorylates the Cdk subunit only after cyclin binding, and so the two steps in Cdk activation are usually ordered as shown here, with cyclin binding occurring first.
The CDK4 gene is located on chromosome 12 in humans. [7] The gene is composed of 4,583 base pairs which together code for the 303 amino acid protein with a molecular mass of 33,730 Da. [7] [8] All CDK proteins, including CDK4, have two lobes: the smaller N-terminal lobe (which contains an inhibitory G-loop), and the C terminal lobe (which contains an activation domain and a T-loop).
The Cyclin D/Cdk4 complex is a multi-protein structure consisting of the proteins Cyclin D and cyclin-dependent kinase 4, or Cdk4, a serine-threonine kinase.This complex is one of many cyclin/cyclin-dependent kinase complexes that are the "hearts of the cell-cycle control system" [1] and govern the cell cycle and its progression.
A Visual Encyclopedia, Dinosaur; A Visual Encyclopedia, Ocean; A Visual Encyclopedia, Science; A Visual Encyclopedia, of the Periodic Table Elements
Cyclins were originally discovered by R. Timothy Hunt in 1982 while studying the cell cycle of sea urchins. [2] [3]In an interview hosted by Jim Al-Khalili and R. Timothy Hunt for "The Life Scientific", which aired on December 13, 2011, explained that the name "cyclin" was originally named after his hobby cycling.