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MDCalc is a free online medical reference for healthcare professionals that provides point-of-care clinical decision-support tools, including medical calculators, scoring systems, and algorithms. [1]
Carboplatin, sold under the brand name Paraplatin among others, is a chemotherapy medication used to treat a number of forms of cancer. [3] This includes ovarian cancer , lung cancer , head and neck cancer , brain cancer , and neuroblastoma . [ 3 ]
As of mid-2006, dacarbazine is commonly used as a single agent in the treatment of metastatic melanoma, [5] [6] and as part of the ABVD chemotherapy regimen to treat Hodgkin's lymphoma, [7] and in the MAID regimen for sarcoma.
eviQ has recommendations for preventing nausea and vomiting. [10] Ensure that patients have sufficient antiemetics for breakthrough emesis with Metoclopramide 10 mg to 20 mg every 4 to 6 hours when necessary OR Prochlorperazine 10 mg PO or 12.5 mg IV every 4 to 6 hours when necessary. [11]
Carboplatin is typically given in combination with either paclitaxel or docetaxel; the typical combination is carboplatin with paclitaxel. [28] [31] Carboplatin is superior to cisplatin in that it is less toxic and has fewer side effects, generally allowing for an improved quality of life in comparison, though both are similarly effective. [31]
ESHAP is an acronym for relatively intensive chemotherapy regimen that is used for salvage therapy in relapsed or refractory lymphomas and Hodgkin's lymphoma.In combination with monoclonal antibody Rituximab it is called R-ESHAP or ESHAP-R.