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Collagenous spherulosis is characterized by a tubular/cribriform architecture with intratubular eosinophilic material that classically is arranged like the spokes of a wheel ("radial spikes"). There is usually no mitotic activity, and two cells populations (epithelial & myoepithelial) are present, like in benign breast glands.
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For breast pathology, also in distinguishing usual ductal hyperplasia (UDH) and papillary lesions (having a mosaic-like pattern) from ductal carcinoma in situ, which is usually negative. [1] Cyclin D1 and CK5/6 staining could be used in concert to distinguish between the diagnosis of papilloma (Cyclin D1 < 4.20%, CK 5/6 positive) or papillary ...
Usual ductal hyperplasia (UDH) is a benign lesion of the breast wherein cells look very similar to normal. It is a spectrum of changes that can range from minimal stratification of cells to proliferations that are just short of atypical ductal hyperplasia .
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Anatomic pathology relates to the processing, examination, and diagnosis of surgical specimens by a physician trained in pathological diagnosis. Clinical pathology involves the laboratory analysis of tissue samples and bodily fluids; procedures may include blood sample analysis, urinalysis, stool sample analysis, and analysis of spinal fluid ...
Although tubular carcinoma has been considered a special-type tumor, [a] recent trend has been to classify it as a low-grade, invasive NOS carcinoma because there is a continuous spectrum from pure tubular carcinomas to mixed NOS [b] carcinomas with tubular features, depending on the percentage of the lesion that displays tubular features.
Fibroadenoma of the breast is a benign tumor composed of a biplastic proliferation of both stromal and epithelial components. [ 12 ] [ 13 ] This biplasia can be arranged in two growth patterns: pericanalicular (stromal proliferation around epithelial structures) and intracanalicular (stromal proliferation compressing the epithelial structures ...