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They are salts. One form is the 1:1 magnesium preparation in salt form with citric acid in a 1:1 ratio (1 magnesium atom per citrate molecule). It contains 11.33% magnesium by weight. Magnesium citrate (sensu lato) is used medicinally as a saline laxative and to empty the bowel before major surgery or a colonoscopy. It is available without a ...
Sodium picosulfate is typically prescribed in a combined formulation with magnesium citrate, an osmotic laxative. This combination is a highly effective laxative, often prescribed to patients for bowel cleansing prior to colonoscopies. [5] [8]
The day before the colonoscopy (or colorectal surgery), the patient is either given a laxative preparation (such as bisacodyl, phospho soda, sodium picosulfate, or sodium phosphate and/or magnesium citrate) and large quantities of fluid, or whole bowel irrigation is performed using a solution of polyethylene glycol and electrolytes.
Prior to surgery, the bowels are typically cleared with a routine called bowel prep. [20] Bowel prep can be performed at home the 1–2 days before surgery or in some instances, occurs in a hospital before the operation. [20] Bowel prep may require magnesium citrate drink to empty the colon. [21] Bowel prep is done to reduce infection risk. [22]
Prolonged use of stimulant laxatives can create drug dependence by damaging the colon's haustral folds, making users less able to move feces through their colon on their own. A study of patients with chronic constipation found that 28% of chronic stimulant laxative users lost haustral folds over the course of one year, while none of the control ...
Sodium citrate saline is one of the most effective osmotic laxatives (secondary in action only to magnesium citrate). [8] Its laxative action is the result of osmotic imbalance that extracts bound water from stool and pulls it back into the large bowel. The increased water content softens the stool and stimulates the bowel to contract (move its ...
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