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Tenosynovial giant cell tumor (TGCT) is a non-malignant tumor defined histologically as inclusions of “osteoclast-like” multinucleated giant cells, hemosiderin, and macrophages. [1] This histology can present one of 2 clinically distinct ways. TGCT tumors often develop from the lining of joints (also known as synovial tissue).
Giant-cell tumor of the tendon sheath, also known as giant-cell synovioma, localized nodular tenosynovitis and localized tenosynovial giant cell tumor or TGCT [1] is a firm lesion, measuring 1 to 3 cm in diameter, and is most commonly attached to the tendons of the fingers, hands, and wrists, with a predilection for the flexor surfaces.
Symptoms may include: Swelling in the extremities (arms or legs), also called peripheral edema; the swelling often is painless. Difficulty in moving the extremity that has the tumor, including a limp. Soreness localized to the area of the tumor or in the extremity. Neurological symptoms. [3] Pain or discomfort: numbness, burning, or "pins and ...
Signs and symptoms are not mutually exclusive, for example a subjective feeling of fever can be noted as sign by using a thermometer that registers a high reading. [7] Because many symptoms of cancer are gradual in onset and general in nature, cancer screening (also called cancer surveillance) is a key public health priority. This may include ...
Villonodular synovitis is a type of synovial swelling.. Types include: Pigmented villonodular synovitis; Giant cell tumor of the tendon sheath; Though they have very different names, they have the same histology, and stain positive for CD68, HAM56, and vimentin. [1]
Pexidartinib, sold under the brand name Turalio, is a kinase inhibitor drug for the treatment of adults with symptomatic tenosynovial giant cell tumor (TGCT) associated with severe morbidity or functional limitations and not amenable to improvement with surgery.
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