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Ubiquitin D is a protein that in humans is encoded by the UBD gene, also known as FAT10. [ 5 ] [ 6 ] [ 7 ] UBD acts like ubiquitin , by covalently modifying proteins and tagging them for destruction in the proteasome.
Blood plasma protein 3.5-5.0 × 10 −2 [1] Aluminum: 1-40 × 10 −8: 1-88 × 10 −8: Selenium : 60–150 ng/mL Aldosterone: Regulates electrolyte balance supine 3-10 × 10 −11: standing, male 6-22 × 10 −11: standing, female 5-30 × 10 −11: Amino acids: Protein building blocks total 3.8-5.3 × 10 −4: nitrogen 4.6-6.8 × 10 −5: 3.0 ...
Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ubiquitously.It was discovered in 1975 [1] by Gideon Goldstein and further characterized throughout the late 1970s and 1980s. [2]
Ubiquitin-binding domains (UBDs) are protein domains that recognise and bind non-covalently to ubiquitin through protein-protein interactions. As of 2019, a total of 29 types of UBDs had been identified in the human proteome. [2] [3] Most UBDs bind to ubiquitin only weakly, with binding affinities in the low to mid μM range.
Ubiquitin-like modifier activating enzyme 1 (UBA1) is an enzyme which in humans is encoded by the UBA1 gene. [ 5 ] [ 6 ] UBA1 participates in ubiquitination and the NEDD8 pathway for protein folding and degradation , among many other biological processes.
Ubiquitin-like proteins (UBLs) are a family of small proteins involved in post-translational modification of other proteins in a cell, usually with a regulatory function. The UBL protein family derives its name from the first member of the class to be discovered, ubiquitin (Ub), best known for its role in regulating protein degradation through covalent modification of other proteins.
7321 216080 Ensembl ENSG00000072401 ENSMUSG00000019927 UniProt P51668 P61080 RefSeq (mRNA) NM_003338 NM_001204880 NM_145420 RefSeq (protein) NP_001191809 NP_003329 NP_663395 Location (UCSC) Chr 10: 58.33 – 58.37 Mb Chr 10: 71.09 – 71.12 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Ubiquitin-conjugating enzyme E2 D1 is a protein that in humans is encoded by the UBE2D1 gene ...
Ubiquitin-associated (UBA) domains are protein domains that non-covalently interact with ubiquitin through protein-protein interactions. Ubiquitin is a small protein that is covalently linked to other proteins as part of intracellular signaling pathways, often as a signal for protein degradation .