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The calcium channel consists of a complex of alpha-1, alpha-2/delta and beta subunits in a 1:1:1 ratio. The S3-S4 linkers of Cav1.2 determine the gating phenotype and modulated gating kinetics of the channel. [8] Cav1.2 is widely expressed in the smooth muscle, pancreatic cells, fibroblasts, and neurons.
Channel iron deposits are an important source of iron ore, with the deposits at Yandi and Robe River accounting for approximately 47% of iron ore mined from the Hamerley Iron province. Although channel iron deposits are typically low-grade at 53% to 57% Fe in-situ, they are composed of goethite-limonite which are hydrated iron oxide species.
The process of iron transportation consists of iron being reduced by ferrireductases that are present on the cell surface or by dietary reductants such as ascorbate . [10] Once the Fe 3+ has been reduced to Fe 2+, the DMT1 transporter protein transports the Fe 2+ ions into the cells that line the small intestine (enterocytes). [10]
Voltage-gated ion-channels are usually ion-specific, and channels specific to sodium (Na +), potassium (K +), calcium (Ca 2+), and chloride (Cl −) ions have been identified. [1] The opening and closing of the channels are triggered by changing ion concentration, and hence charge gradient, between the sides of the cell membrane. [2]
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Steel with 2.1% Carbon by weight begins melting at 1,130 °C (2,070 °F), and is completely molten upon reaching 1,315 °C (2,399 °F). 'Steel' with more than 2.1% Carbon is no longer Steel, but is known as Cast iron .
[1] A depiction of Two-Pore Channel 2 (TPC2). There are two domains, labelled I and II. A pore exists in each domain, as labeled by P. Adapted from image in Grimm, C. et al. "Role Of TRPML And Two-Pore Channels In Endolysosomal Cation Homeostasis". Journal of Pharmacology and Experimental Therapeutics 342.2 (2012): 236–244. Web.
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