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Myasthenia gravis, or MG, is a chronic autoimmune neuromuscular disorder that causes muscle weakness and fatigue. Myasthenia gravis is one of the rarest and most concerning muscular disorders ...
In diseases such as myasthenia gravis, the end plate potential (EPP) fails to effectively activate the muscle fiber due to an autoimmune reaction against acetylcholine receptors, resulting in muscle weakness and fatigue. [2] Myasthenia gravis is caused most commonly by auto-antibodies against the acetylcholine receptor.
Myasthenia gravis affects 50 to 200 people per million. [3] [4] It is newly diagnosed in 3 to 30 people per million each year. [13] Diagnosis has become more common due to increased awareness. [13] Myasthenia gravis most commonly occurs in women under the age of 40 and in men over the age of 60. [1] [5] [14] It is uncommon in children. [1]
A neuromuscular junction (or myoneural junction) is a chemical synapse between a motor neuron and a muscle fiber. [1] It allows the motor neuron to transmit a signal to the muscle fiber, causing muscle contraction. [2] Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy.
True muscle weakness is a primary symptom of a variety of skeletal muscle diseases, including muscular dystrophy and inflammatory myopathy. It occurs in neuromuscular junction disorders, such as myasthenia gravis. Muscle weakness can also be caused by low levels of potassium and other electrolytes within muscle cells. It can be temporary or ...
Repetitive nerve stimulation is a variant of the nerve conduction study where electrical stimulation is delivered to a motor nerve repeatedly several times per second. By observing the change in the muscle electrical response (CMAP) after several stimulations, a physician can assess for the presence of a neuromuscular junction disease, and differentiate between presynaptic and postsynaptic ...
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