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Ketamine, 200mg in 20ml (0.1-1mg/kg) Ketamine, 500mg in 10ml (4mg/kg of ideal body weight) Salbutamol 500mcg in 1ml (Adults; max dose 1mg, Children 2-12 years 15mcg/kg) Magnesium 5g in 10ml (Asthma: 2g, Pre/Eclampsia: 4g, toxidrome: 2g) Calcium Gluconate 10% w/v in 10ml (Toxidrome & hyperkalaemia: up to 20mls)
Ketamine potentiates the sedative effects of propofol [85] and midazolam. [86] Naltrexone potentiates psychotomimetic effects of a low dose of ketamine, [87] while lamotrigine [38] and nimodipine [39] decrease them. Clonidine reduces the increase of salivation, heart rate, and blood pressure during ketamine anesthesia and decreases the ...
In toxicology, the lowest published toxic dose (Toxic Dose Low, TD Lo) is the lowest dosage per unit of bodyweight (typically stated in milligrams per kilogram) of a substance known to have produced signs of toxicity in a particular animal species. [1]
In toxicology, the lethal dose (LD) is an indication of the lethal toxicity of a given substance or type of radiation. Because resistance varies from one individual to another, the "lethal dose" represents a dose (usually recorded as dose per kilogram of subject body weight) at which a given percentage of subjects will die. The lethal ...
An equianalgesic chart can be a useful tool, but the user must take care to correct for all relevant variables such as route of administration, cross tolerance, half-life and the bioavailability of a drug. [5] For example, the narcotic levorphanol is 4–8 times stronger than morphine, but also has a much longer half-life. Simply switching the ...
Authorities have opened an investigation into how Matthew Perry received the supply of ketamine that killed him, police said Tuesday. Los Angeles police are working with the U.S. Drug Enforcement ...
The median lethal dose of a substance is defined as the dose that leads to death in 50% of the tested population. It is a significant parameter in toxicology study and indicates the acute toxicity of a particular substance. LD50 is usually expressed in the weight of the chemical administered in milligram per unit of body weight (mg/kg). [29]
Acceptable daily intake or ADI is a measure of the amount of a specific substance (originally applied for a food additive, later also for a residue of a veterinary drug or pesticide) in food or drinking water that can be ingested (orally) daily over a lifetime without an appreciable health risk. [1]
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