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In traumatic brain injury (TBI), primary brain injury occurs during the initial insult, and results from displacement of the physical structures of the brain. [1] Secondary brain injury occurs gradually and may involve an array of cellular processes. [1] [2] Secondary injury, which is not caused by mechanical damage, can result from the primary ...
The adolescent brain is 60 times more sensitive to components of the metabolic chain reaction that occurs after trauma, resulting in more diffuse cerebral swelling. [41] After the initial concussion, the children and young adults are more likely to sustain a second impact within the first two weeks. [40]
The relative risk of post-traumatic seizures (PTS) increases with the severity of traumatic brain injury (TBI). [128] A CT of the head years after a traumatic brain injury showing an empty space where the damage occurred marked by the arrow. Improvement of neurological function usually occurs for two or more years after the trauma.
A sequela (UK: / s ɪ ˈ k w iː l ə /, [1] US: / s ɪ ˈ k w ɛ l ə /; [2] [3] usually used in the plural, sequelae /-iː /) is a pathological condition resulting from a disease, injury, therapy, or other trauma. Derived from the Latin word meaning "sequel", it is used in the medical field to mean a complication or condition following a ...
Ischemic brain injury resulting from an insufficient blood supply to the brain, is one of the leading causes of secondary brain damage after head trauma. [4] Vascular injury usually causes death shortly after an injury. [4] Although it is a diffuse type of brain injury itself, diffuse vascular injury is generally more likely to be caused by ...
A common category with the greatest number of injuries is traumatic brain injury (TBI) following physical trauma or head injury from an outside source, and the term acquired brain injury (ABI) is used in appropriate circles to differentiate brain injuries occurring after birth from injury, from a genetic disorder (GBI), or from a congenital ...
Immunoreactive axonal profiles are observed as either granular (B, G, H) or more elongated, fusiform (F) swellings in the corpus callosum and the brain stem (H) at 24h post traumatic brain injury. Example of APP immunoreactive neurons (arrow heads) observed in the cortex underneath the impact site (E, G). No APP staining was observed in healthy ...
Closed head injury (coup contrecoup) can damage more than the impact sites on the brain, as axon bundles may be torn or twisted, blood vessels may rupture, and elevated intracranial pressure can distort the walls of the ventricles. [7] [10] [11] Diffuse axonal injury is a key pathology in concussive brain injury. [5] The visual system may be ...