Ads
related to: ace inhibitors side effects elderly- Co-Pay Program
Resources
to Support Your Patients
- Dosing & Administration
Efficacy, Safety, and Dosing
Information for HCPs
- Trial Results
See Clinical Data
and Trial
- Request Samples
Get patients started
with a 14-day sample
- Co-Pay Program
Search results
Results From The WOW.Com Content Network
Angiotensin-converting-enzyme inhibitors (ACE inhibitors) are a class of medication used primarily for the treatment of high blood pressure and heart failure. [1] [2] This class of medicine works by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart.
Common side effects include headaches, dizziness, fatigue, and cough. [1] Serious side effects may include liver problems, angioedema, kidney problems, and high blood potassium. [1] Use in pregnancy and breastfeeding is not recommended. [5] It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity. [1]
The cardioprotective effects of ACE inhibitors are mediated through a combination of angiotensin II inhibition and bradykinin proliferation. [8] [9] Increased levels of bradykinin stimulate in the production of prostaglandin E 2 [10] and nitric oxide, [9] which cause vasodilation and continue to exert antiproliferative effects. [8]
There are fixed-dose combination drugs, such as ACE inhibitor and thiazide combinations. [19] Notable side effects of ACEis include dry cough, high blood levels of potassium, fatigue, dizziness, headaches, loss of taste and a risk for angioedema. [20]
[2] [12] Risk of hypotension and hyperkalemia increases when valsartan/hydrochlorothiazide is used with ACE inhibitors or aliskiren. [ 2 ] [ 13 ] Less common side effects that occur less than 1% of the time include angina pectoris , rash , syncope , abdominal pain, and vertigo .
Serious side effects may include liver problems, low blood pressure, angioedema, kidney problems, and high blood potassium. [3] Use in pregnancy and breastfeeding is not recommended. [4] It is among a class of drugs called ACE inhibitors and works by decreasing renin-angiotensin-aldosterone system activity. [3]