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The post Black Dog ‘Buster’ Turns White Due To Rare Genetic Condition appeared first on DogTime. ... The reason behind Buster’s drastic change is vitiligo, a genetic condition often seen in ...
My dog Buster has the skin condition vitiligo. It causes depigmentation of the skin (and fur). These photos beautifully capture how vitiligo has made Buster even more unique: November 2021 ...
Some genetic conditions that result in a "leucistic" appearance include piebaldism, Waardenburg syndrome, vitiligo, Chédiak–Higashi syndrome, flavism, isabellinism, xanthochromism, axanthism, amelanism, and melanophilin mutations. Pale patches of skin, feathers, or fur (often referred to as "depigmentation") can also result from injury.
Type 2E is caused by an autosomal dominant mutation in the gene SOX10. [4] Rarely, a mutation in a gene other than those currently known may be responsible for a Waardenburg syndrome with features of type 2. This is usually initially classified as simply type 2 but may be given its own subtype once a gene or locus is identified and established. [7]
Incidences of autoimmune skin diseases can vary based on several factors. Some of these factors include the breed, age, and sex of the dog, along with individual genetics and environmental factors. [3] In terms of vitiligo, certain breeds of dogs have a higher chance of developing the disease based on their genetics.
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In many dog breeds the Piebald gene is common. The white parts of the fur interrupt the pigmented coat patterns. Dogs that may have a spotted or multicolored coat, are often called piebald if their body is almost entirely white or another solid color with spotting and patches on the head and neck.
The condition is very common in mice, rabbits, dogs, sheep, deer, cattle and horses—where selective breeding has increased the incidence of the mutation—but occurs among chimpanzees and other primates only as rarely as among humans. Piebaldism is unrelated to conditions such as vitiligo or poliosis.