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In the field of molecular biology, the ETS (E26 transformation-specific [2] or Erythroblast Transformation Specific [3]) family is one of the largest families of transcription factors and is unique to animals. There are 28 genes in humans, [4] 27 in the mouse, 10 in Caenorhabditis elegans and 9 in Drosophila.
ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene. [ 5 ] [ 6 ] The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily.
ETS Like-1 protein Elk-1 is a protein that in humans is encoded by the ELK1. [5] Elk-1 functions as a transcription activator . It is classified as a ternary complex factor (TCF), a subclass of the ETS family , which is characterized by a common protein domain that regulates DNA binding to target sequences.
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. [6] The nuclear protein binds to a purine-rich sequence known as the PU-box found on enhancers of target genes, and regulates their expression in coordination with other transcription factors and cofactors.
There are approximately 2800 proteins in the human genome that contain DNA-binding domains, ... 3.5.2 Family: Ets-type; 3.5.3 Family: Interferon regulatory factors;
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ERG (ETS-related gene) is an oncogene. [ 5 ] [ 6 ] [ 7 ] ERG is a member of the ETS (erythroblast transformation-specific) family of transcription factors. [ 8 ] The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator.
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