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Multiple ETS factors have been found to be associated with cancer, such as through gene fusion. For example, the ERG ETS transcription factor is fused to the EWS gene, resulting in a condition called Ewing's sarcoma. [6] The fusion of TEL to the JAK2 protein results in early pre-B acute lymphoid leukaemia. [7]
ERG (ETS-related gene) is an oncogene. [ 5 ] [ 6 ] [ 7 ] ERG is a member of the ETS (erythroblast transformation-specific) family of transcription factors. [ 8 ] The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator.
SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene. [5] [6] [7] PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM] [7]
Ets1 directly interacts with various transcription factors. Their interaction results in formation of multiprotein complexes. When Ets1 interacts with other transcription factors (Runx1, Pax5, TFE3, and USF1) its final effect on transcription depends on whether C-terminal domain is phosphorylated.
ETS Like-1 protein Elk-1 is a protein that in humans is encoded by the ELK1. [5] Elk-1 functions as a transcription activator.It is classified as a ternary complex factor (TCF), a subclass of the ETS family, which is characterized by a common protein domain that regulates DNA binding to target sequences.
Fli-1 is a member of the ETS transcription factor family that was first identified in erythroleukemias induced by Friend Murine Leukemia Virus ().Fli-1 is activated through retroviral insertional mutagenesis in 90% of F-MuLV-induced erythroleukemias.
2114 23872 Ensembl ENSG00000157557 ENSMUSG00000022895 UniProt P15036 P15037 RefSeq (mRNA) NM_001256295 NM_005239 NM_011809 RefSeq (protein) NP_001243224 NP_005230 NP_035939 Location (UCSC) Chr 21: 38.81 – 38.82 Mb Chr 16: 95.5 – 95.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein C-ETS2 is a protein that in humans is encoded by the ETS2 gene. The protein encoded by this ...
The protein encoded by this gene is a member of an epithelium-specific subclass of the ETS transcription factor family.In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate.