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Lumateperone was approved for medical use in the United States in December 2019 with an initial indication for schizophrenia, [4] [5] and became available in February 2020. [2] It has since demonstrated efficacy in bipolar depression and received FDA approval in December 2021 for depressive episodes associated with both bipolar I and II disorders.
Quetiapine and the combination of olanzapine and fluoxetine have both demonstrated effectiveness in bipolar depression. [21] In light of recent evidence, olanzapine (Zyprexa) has been FDA approved as an effective monotherapy for the maintenance of bipolar disorder. [22]
Olanzapine/fluoxetine was approved by the U.S. Food and Drug Administration (FDA) to treat the depressive episodes of bipolar I disorder in 2003. [1] In 2009, it was granted approval for the treatment of treatment-resistant depression.
The FDA hasn’t approved ketamine to treat bipolar disorder. However, it’s been used off-label to manage pain and depression since the 1970s and may have antidepressant and anti-suicidal ...
Levosulpiride – approved in low doses for major depressive disorder [11] Lumateperone (Caplyta) – approved as a monotherapy for bipolar depression; Lurasidone (Latuda) – approved as a monotherapy for bipolar depression; Quetiapine (Seroquel) – approved as a monotherapy for bipolar depression
In 2013, it was approved in Canada and by the U.S. Food and Drug Administration (FDA) to treat bipolar depression, either as monotherapy or adjunctively with lithium or valproate. [15] [16] It has no effect on manic symptoms and is more potent for treating major depressive disorder or depressive episodes associated with bipolar disorder ...
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