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The side effects of penicillin are bodily responses to penicillin and closely related antibiotics that do not relate directly to its effect on bacteria. A side effect is an effect that is not intended with normal dosing. [1] Some of these reactions are visible and some occur in the body's organs or blood.
Serious side effects may include Clostridioides difficile colitis or anaphylaxis. [7] While usable in those with kidney problems, the dose may need to be decreased. [7] Its use during pregnancy and breastfeeding appears to be generally safe. [7] [8] Ampicillin was discovered in 1958 and came into commercial use in 1961.
Other serious side effects include low blood potassium and myocarditis (inflammation of the heart). [3] It appears to be relatively safe in pregnancy. [4] There is a lipid formulation that has a lower risk of side effects. [4] It is in the polyene class of medications and works in part by interfering with the cell membrane of the fungus. [3] [4]
Additional side effects can result from interaction with other drugs, such as the possibility of tendon damage from the administration of a quinolone antibiotic with a systemic corticosteroid. [ 51 ] Some antibiotics may also damage the mitochondrion , a bacteria-derived organelle found in eukaryotic, including human, cells. [ 52 ]
It’s important to continue using your medication for the entire treatment period, even if your skin and hair improve relatively early. Stopping treatment early may increase your risk of ...
A temperature rise above 38 °C (100.4 °F) maintained over 24 hours or recurring during the period from the end of the first to the end of the 10th day after childbirth or abortion. (ICD-10) Oral temperature of 38 °C (100.4 °F) or more on any two of the first ten days postpartum.
Ampicillin/sulbactam is contraindicated in individuals who have a history of a penicillin allergy. Symptoms of allergic reactions may range from rash to potentially life-threatening conditions, such as anaphylaxis. Patients who have asthma, eczema, hives, or hay fever are more likely to develop undesirable reactions to any of the penicillins. [10]
Ampicillin/flucloxacillin also known as co-fluampicil (), and sold under the tradename Magnapen, is a combination drug of the two β-lactam antibiotics, ampicillin and flucloxacillin, both in equal amounts, available in a capsule and as a liquid, both taken by mouth, and as a formulation which can be given by injection into muscle or vein.