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Nortriptyline is an active metabolite of amitriptyline by demethylation in the liver. Chemically, it is a secondary amine dibenzocycloheptene and pharmacologically it is classed as a first-generation antidepressant. [36] Nortriptyline may also have a sleep-improving effect due to antagonism of the H 1 and 5-HT 2A receptors. [37]
ATC code N06 Psychoanaleptics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Nortriptyline reaches 10% higher level in the blood plasma than the parent drug amitriptyline and 40% greater area under the curve, and its action is an important part of the overall action of amitriptyline. [5] [9] Another active metabolite is (E)-10-hydroxynortriptyline, which is a norepinephrine uptake inhibitor four times weaker than ...
Tricyclic antidepressants such as amitriptyline or nortriptyline and medications from the selective serotonin reuptake inhibitor (SSRI) group may improve overall symptoms and reduce pain. [7] Patient education and a good doctor–patient relationship are an important part of care.
Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Nortriptyline. PubMed provides review articles from the past five years (limit to free review articles)
The Vietnamese Wikipedia initially went online in November 2002, with a front page and an article about the Internet Society.The project received little attention and did not begin to receive significant contributions until it was "restarted" in October 2003 [3] and the newer, Unicode-capable MediaWiki software was installed soon after.
Other secondary amine TCAs include desipramine and nortriptyline. [ 26 ] [ 27 ] The chemical name of protriptyline is 3-(5 H -dibenzo[ a , d ][7]annulen-5-yl)- N -methylpropan-1-amine and its free base form has a chemical formula of C 19 H 21 N 1 with a molecular weight of 263.377 g/mol. [ 28 ] The drug is used commercially mostly as the ...
Vietnamese (tiếng Việt) is an Austroasiatic language spoken primarily in Vietnam where it is the official language. It belongs to the Vietic subgroup of the Austroasiatic language family. [5] Vietnamese is spoken natively by around 85 million people, [1] several times as many as the rest of the Austroasiatic family combined. [6]