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A diagnosis of melanoma is supported by the presence of the S-100 protein marker. HMB-45 is a monoclonal antibody that reacts against an antigen present in melanocytic tumors such as melanomas. It is used in anatomic pathology as a marker for such tumors. The antibody was generated to an extract of melanoma.
Superficial spreading melanoma (SSM) is a type of skin cancer that typically starts as an irregularly edged dark spot typically on sun-exposed part of the body. [ 2 ] [ 3 ] The colour may be variable with dark, light and reddish shades; occasionally no color at all. [ 2 ]
In medicine, Breslow's depth was used as a prognostic factor in melanoma of the skin. It is a description of how deeply tumor cells have invaded. Currently, the standard Breslow's depth has been replaced by the AJCC depth, in the AJCC staging system of melanoma. Originally, Breslow's depth was divided into 5 stages. [1]
The prognosis of acral lentiginous melanoma is based on multiple factors including gender, age, race, Breslow depth, staging, and sentinel lymph node positivity. [7] Out of these factors, it is believed that sentinel lymph node positivity provides the strongest prediction of cancer recurrence and death.
Treatments for melanoma result in higher survival rate than people may expect. But a key to this is early detection. Currently there is a 99% five-year survival rate for early detected melanoma.
Mellencamp has documented her cancer journey on social media, sharing the same graphic photo of her surgery scar in December 2023. At the time, she'd been diagnosed with her 13th melanoma after ...