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Opioid-induced endocrinopathy (OIE) is a complication of chronic opioid treatment. [ 1 ] [ 2 ] [ 3 ] It is a common name for all hypothalamo-pituitary axis disorders, which can be observed mostly after long term use of opioids, both as a treatment and as a substance of abuse .
The heroin and opioid abuse epidemic is hitting America hard with heroin use more than doubling in the past decade among young adults, according to the CDC. While the dire statistics tell the ...
The study, which was published in PNAS Nexus on October 14, may help explain why women are more prone to experience chronic pain and tend to respond less to treatment with opioid medications. Here ...
Different drug classes have different side effects. Long-term medical conditions induced by opioid include infection, hyperalgesia, opioid-induced bowel syndrome, opioid-related leukoencephalopathy and opioid amnestic syndrome. [32] Misuse of prescribed opioids medications is associated with increased morbidity and mortality. [37]
The opioid epidemic affects women and men differently. [28] For instance, women are more likely than men to report recent and non-recent prescription opioid use. [29] Women are also more likely to have chronic pain than men are. [30] In cases of domestic abuse and rape, women are prescribed pain medicine more than men. [30]
The opioid epidemic took hold in the U.S. in the 1990s. Percocet, OxyContin and Opana became commonplace wherever chronic pain met a chronic lack of access to quality health care, especially in Appalachia. The Centers for Disease Control and Prevention calls the prescription opioid epidemic the worst of its kind in U.S. history.
Opioid-induced hyperalgesia (OIH) or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia, is an uncommon condition of generalized pain caused by the long-term use of high dosages of opioids [1] such as morphine, [2] oxycodone, [3] and methadone. [4] [5] OIH is not necessarily confined to the original affected site. [6]
The "CDC Clinical Practice Guideline for Prescribing Opioids for Pain-United States, 2022" provides recommendations related to opioid misuse, OUD, and opioid overdoses. [18] It reports a lack of clinical evidence that "abuse-deterrent" opioids (e.g., OxyContin), as labeled by the U.S. Food and Drug Administration , are effective for OUD risk ...