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The Shiga toxins target ribosomal RNA, which inhibits protein synthesis and causes apoptosis. [14] The reason EHEC are symptomless in cattle is because the cattle do not have vascular expression of Gb3 unlike humans. Thus, the Shiga toxins cannot pass through the intestinal epithelium into circulation. [5]
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A fact from Shigatoxigenic and verotoxigenic Escherichia coli appeared on Wikipedia's Main Page in the Did you know column on 12 June 2011 (check views). The text of the entry was as follows: Did you know... that Shiga-like toxin-producing Escherichia coli are responsible for tens of thousands of cases of foodborne illness a year?
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Shiga-like toxin (SLT) is a historical term for similar or identical toxins produced by Escherichia coli. [3] The most common sources for Shiga toxin are the bacteria S. dysenteriae and some serotypes of Escherichia coli (shigatoxigenic or STEC), which include serotypes O157:H7 , and O104:H4 .
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