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Carcinogenic parasites are parasitic organisms that depend on other organisms (called hosts) for their survival, and cause cancer in such hosts.Three species of flukes are medically-proven carcinogenic parasites, namely the urinary blood fluke (Schistosoma haematobium), the Southeast Asian liver fluke (Opisthorchis viverrini) and the Chinese liver fluke (Clonorchis sinensis).
Schistosoma haematobium (urinary blood fluke) is a species of digenetic trematode, belonging to a group (genus) of blood flukes (Schistosoma). It is found in Africa and the Middle East. It is the major agent of schistosomiasis, the most prevalent parasitic infection in humans. [1]
Calcification of the bladder wall caused by deposition of calcium around the Schistosoma eggs on a plain X-ray image of the pelvis, in a 44-year-old sub-Saharan man, due to urinary schistosomiasis. The worms of S. haematobium migrate to the veins around the bladder and ureters where they reproduce. [29] [33] S. haematobium can produce up to ...
Schistosoma haematobium: kidney, bladder, ureters, lungs, skin urine Africa, Middle East skin exposure to water contaminated with infected Bulinus sp. snails Schistosomiasis by Schistosoma japonicum: Schistosoma japonicum: intestine, liver, spleen, lungs, skin stool China, East Asia, Philippines
Schistosoma is a genus of trematodes, commonly known as blood flukes.They are parasitic flatworms responsible for a highly significant group of infections in humans termed schistosomiasis, which is considered by the World Health Organization to be the second-most socioeconomically devastating parasitic disease (after malaria), infecting millions worldwide.
Parasitic infections strongly associated with cancer include Schistosoma haematobium (squamous cell carcinoma of the bladder) and the liver flukes, Opisthorchis viverrini and Clonorchis sinensis (cholangiocarcinoma). [68] Inflammation triggered by the worm's eggs appears to be the cancer-causing mechanism.
Most prominent is schistosomiasis, in which the eggs of the flatworm Schistosoma haematobium can become lodged in the bladder wall, causing chronic bladder inflammation and repeated bladder infections. [55] In places with endemic schistosomiasis, up to 16% of bladder cancer cases are caused by prior Schistosoma infection. [55]
Immature developmental stages of schistosomes are found in molluscs and adults occur in vertebrates. The best studied group, the blood flukes of the genus Schistosoma, infect and cause disease in humans. Other genera which are infective to non-human vertebrates can cause mild rashes in humans.