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Isoelectronicity is a phenomenon observed when two or more molecules have the same structure (positions and connectivities among atoms) and the same electronic configurations, but differ by what specific elements are at certain locations in the structure. For example, CO, NO +, and N 2 are isoelectronic, while CH 3 COCH 3 and CH 3 N = NCH 3 are ...
anon, Guidance for Industry: Container Closure Systems for Packaging Human Drugs and Biologics, May 1999, Food and Drug Administration, Center for Drug Evaluation and Research, Lockhart, H., and Paine, F.A., "Packaging of Pharmaceuticals and Healthcare Products", 2006, Blackie, ISBN 0-7514-0167-6
It could not distinguish between drugs released by manufacturers as opposed to the pharmaceutical industry. It also found that an estimated 250 million pounds of pharmaceuticals and contaminated packaging were discarded by hospitals and long-term care facilities. [12]
In drug discovery, either a large series of structural analogs of an initial lead compound are created and tested as part of a structure–activity relationship study [5] or a database is screened for structural analogs of a lead compound. [6] Chemical analogues of illegal drugs are developed and sold in
The first ODT form of a drug to get approval from the U.S. Food and Drug Administration (FDA) was a Zydis ODT formation of Claritin in December 1996. [19] It was followed by a Zydis ODT formulation of Klonopin ( clonazepam ) in December 1997, [ 20 ] and a Zydis ODT formulation of Maxalt ( rizatriptan ) in June 1998. [ 21 ]
By the late 1980s, BFS had been well-established in the packaging industry, especially for packaging pharmaceutical and healthcare products. [14] During the 1980s and 1990s, BFS came into use for the now common small volume unit-dosage forms. [12] Since the early 2000s, BFS has been emerging as the preferred packaging process for parenteral ...
A deuterated drug is a small molecule medicinal product in which one or more of the hydrogen atoms in the drug molecule have been replaced by its heavier stable isotope deuterium. Because of the kinetic isotope effect , deuterium-containing drugs may have significantly lower rates of metabolism , and hence a longer half-life .
Modified atmosphere packaging (MAP) is the practice of modifying the composition of the internal atmosphere of a package (commonly food packages, drugs, etc.) in order to improve the shelf life. [ 1 ] [ 2 ] The need for this technology for food arises from the short shelf life of food products such as meat, fish, poultry, and dairy in the ...