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Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
3274 15466 Ensembl ENSG00000113749 ENSMUSG00000034987 UniProt P25021 P97292 RefSeq (mRNA) NM_001131055 NM_022304 NM_001367711 NM_001393460 NM_001393461 NM_001010973 NM_008286 RefSeq (protein) NP_001124527 NP_001354640 NP_001010973 Location (UCSC) Chr 5: 175.66 – 175.71 Mb Chr 13: 54.35 – 54.39 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse H 2 receptors are a type of histamine ...
[2] [7] [11] While all members of the H1 group and the prokaryotic members of the H2 group function as monomers, eukaryotic H2 enzymes are obligate heterotrimers. [2] [7] Prokaryotic HIII enzymes are members of the broader H2 group and share most structural features with H2, with the addition of an N-terminal TATA box binding domain. [7]
Functional group interconversion can be used in retrosynthetic analysis to plan organic synthesis. A functional group is a group of atoms in a molecule with distinctive chemical properties, regardless of the other atoms in the molecule. The atoms in a functional group are linked to each other and to the rest of the molecule by covalent bonds.
Seven men from Chile have been charged in Florida federal court with orchestrating burglaries at the homes of prominent professional athletes around the country, according to a criminal complaint.
The study does have some limitations when attempting to compare between different viruses, the doctor noted. "Patients were required to self-report their symptoms," he said.
The differences between the core canonical histones and their variants can be summarized as follows: (1) canonical histones are replication-dependent and are expressed during the S-phase of cell cycle whereas histone variants are replication-independent and are expressed during the whole cell cycle; (2) in animals, the genes encoding canonical ...
The avian influenza is a disease previously known to primarily spread between birds and poultry, not other species. However, one specific subtype of bird flu called the H5N1 virus has crossed ...