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Citicoline may have neuroprotective effects due to its preservation of cardiolipin and sphingomyelin, preservation of arachidonic acid content of phosphatidylcholine and phosphatidylethanolamine, partial restoration of phosphatidylcholine levels, and stimulation of glutathione synthesis and glutathione reductase activity.
1-Oleoyl-2-palmitoyl-phosphatidylcholine. Phosphatidylcholines (PC) are a class of phospholipids that incorporate choline as a headgroup.They are a major component of biological membranes and can easily be obtained from a variety of readily available sources, such as egg yolk or soybeans, from which they are mechanically or chemically extracted using hexane.
Phosphatidylethanolamine N-methyltransferase (abbreviated PEMT) is a transferase enzyme (EC 2.1.1.17) which converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver. [ 5 ] [ 6 ] [ 7 ] In humans it is encoded by the PEMT gene within the Smith–Magenis syndrome region on chromosome 17 .
Drug-drug interactions can occur when certain drugs are administered at the same time. Effects of this can be additive (outcome is greater than those of one individual drug), less than additive (therapeutic effects are less than those of one individual drug), or functional alterations (one drug changes how another is absorbed, distributed, and ...
Phosphocholine is made in a reaction, catalyzed by choline kinase, that converts ATP and choline into phosphocholine and ADP. Phosphocholine is a molecule found, for example, in lecithin . In nematodes and human placentas , phosphocholine is selectively attached to other proteins as a posttranslational modification to suppress an immune ...
For targeted local delivery of Zotarolimus to the artery, the drug is incorporated into a methacrylate-based copolymer that includes a synthetic form of phosphorylcholine. This use of biomimicry , or the practice of using polymers that occur naturally in biology, provides a coating with minimal thrombus deposition and no adverse clinical effect ...
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In enzymology, a phosphatidylcholine synthase (EC 2.7.8.24) is an enzyme that catalyzes the chemical reaction. CDP-diacylglycerol + choline CMP + phosphatidylcholine. Thus, the two substrates of this enzyme are CDP-diacylglycerol and choline, whereas its two products are CMP and phosphatidylcholine.