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  2. Spironolactone - Wikipedia

    en.wikipedia.org/wiki/Spironolactone

    Low-dose spironolactone is generally very well tolerated. [63] Even higher doses of spironolactone, such as 100 mg/day, are well tolerated in most individuals. [63] Dose-dependent side effects of spironolactone include menstrual irregularities, breast tenderness, and enlargement, orthostatic hypotension, and hyperkalemia. [63]

  3. Pharmacodynamics of spironolactone - Wikipedia

    en.wikipedia.org/wiki/Pharmacodynamics_of...

    Spironolactone has been found to be effective in the treatment of hirsutism in women at a dosage of as low as 50 mg/day. [60] At dosages of 100 mg/day and 200 mg/day, observed reductions in hair shaft diameter were 19% ± 8% and 30% ± 3%, respectively (p = 0.07).

  4. RALES (trial) - Wikipedia

    en.wikipedia.org/wiki/RALES_(trial)

    The trial was stopped early because the beneficial effect of spironolactone on all-cause death exceeded the prespecified discontinuation requirements. Spironolactone reduced the risk of death by 30% compared to placebo. Additionally, there was a 35% reduction in the risk of hospitalization for worsening heart failure in the spironolactone group.

  5. Drugmakers to raise US prices on over 250 medicines starting ...

    www.aol.com/news/drugmakers-raise-us-prices-over...

    The median price increase of the drugs being hiked Jan. 1 is 4.5%, which is in line with the median for all price increases last year. Drugmakers to raise US prices on over 250 medicines starting ...

  6. Lilly slashes prices on lowest doses of weight loss ... - AOL

    www.aol.com/news/lilly-slashes-prices-two-lowest...

    Under the new pricing plan, a month’s supply of the lowest dose, 2.5 milligrams, will cost $399, while a month’s supply of the 5 mg dose will cost $549. That’s down from a monthly list price ...

  7. Here's what to know about Medicare's new $2,000 prescription ...

    www.aol.com/heres-know-medicares-2-000-174637852...

    Millions of Medicare enrollees are likely to see relief in 2025 when a $2,000 cap on out-of-pocket prescription drug-spending goes into effect.

  8. Potassium-sparing diuretic - Wikipedia

    en.wikipedia.org/wiki/Potassium-sparing_diuretic

    [12] [13] Due to its activity as an androgen receptor antagonist and progesterone receptor agonist, spironolactone causes adverse effects, including gynecomastia or decreased libido in males and menstrual abnormalities in females. [14] Spironolactone also causes hyperkalemia [15] and renal insufficiency. [16]

  9. Eli Lilly Cuts Zepbound Prices by 50% With Single-Dose ... - AOL

    www.aol.com/lifestyle/eli-lilly-cuts-zepbound...

    Officials at Eli Lilly, the manufacturer of the drug, have announced plans to sell Zepbound in 2.5 milligram and 5 mg single-vial doses at a discount of 50% or higher compared to the list price of ...