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CinCor Pharma Inc (NASDAQ: CINC) announced topline results and completion of its Phase 2 HALO trial of baxdrostat in patients with uncontrolled hypertension taking up to two blood pressure ...
CinCor (CINC) plummets as its phase II study, HALO, evaluating its lead candidate baxdrostat for hypertension, fails to meet its primary endpoint.
Baxdrostat is an investigational drug that is being evaluated for the treatment of hypertension. [1] It is an aldosterone synthase inhibitor. [2] [3] References
Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
Common side effects include dizziness, headaches, diarrhea, and back pain. [2] Serious side effects may include kidney problems, low blood pressure, and angioedema. [2] Use in pregnancy may harm the fetus and use when breastfeeding is not recommended. [3] It is an angiotensin II receptor antagonist and works by blocking the effects of ...
Chlortalidone is considered a first-line medication for treatment of high blood pressure. [2] Some recommend chlortalidone over hydrochlorothiazide. [1] [15] A meta-analysis of randomized controlled trials found that chlortalidone is more effective than hydrochlorothiazide for lowering blood pressure, while the two drugs have similar toxicity.
The attorney for an 85-year-old white man who shot Ralph Yarl after the teenage Black honor student came to his Kansas City, Missouri, home by mistake has requested a psychological examination for ...
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