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Intravenous sodium bicarbonate is indicated in the treatment of metabolic acidosis, such as can occur in severe kidney disease, diabetic ketoacidosis [citation needed], circulatory insufficiency, extracorporeal circulation of blood, in hemolysis requiring alkalinization of the urine to avoid nephrotoxicity of blood pigments, and certain drug intoxications, such as by barbiturate overdose ...
Absolute bioavailability refers to the bioavailability of a drug when administered via an extravascular dosage form (i.e. oral tablet, suppository, subcutaneous, etc.) compared with the bioavailability of the same drug administered intravenously (IV). This is done by comparing the AUC of the non-intravenous dosage form with the AUC for the drug ...
Mathematically, if the change in the numerator is similar to the change in the denominator, the delta ratio will be close to 1. Since the anions are unable to diffuse out of the bloodstream, while bicarbonate and hydrogen ions diffuse with ease (as H 2 CO 3, carbonic acid), the usual result will be closer to a delta ratio of 1 to 2.
They are used to treat and prevent constipation. Laxatives vary as to how they work and the side effects they may have. Certain stimulant , lubricant , and saline laxatives are used to evacuate the colon for rectal and bowel examinations, and may be supplemented by enemas under certain circumstances.
When peripheral infusions are necessary, the burning can be reduced by diluting the potassium in larger amounts of fluid, or adding a small dose of lidocaine to the intravenous fluid, [31] although adding lidocaine may increase the likelihood of medical errors. [33] Even in severe hypokalemia, oral supplementation is preferred given its safety ...
In chemistry and biochemistry, the Henderson–Hasselbalch equation = + ([] []) relates the pH of a chemical solution of a weak acid to the numerical value of the acid dissociation constant, K a, of acid and the ratio of the concentrations, [] [] of the acid and its conjugate base in an equilibrium.
Plasma osmolality measures the body's electrolyte–water balance. [1] There are several methods for arriving at this quantity through measurement or calculation. Osmolality and osmolarity are measures that are technically different, but functionally the same for normal use.
In physiology and medicine, the body surface area (BSA) is the measured or calculated surface area of a human body.For many clinical purposes, BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass.