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Evidence-based, trauma-focused psychotherapy is the first-line treatment for PTSD. [8] [9] [6] Psychotherapy is defined as a treatment where a therapist and patient build a therapeutic relationship and focus on the patient's thoughts, attitudes, affect, behavior, and social development to lessen the patient's psychopathologies and functional impairment.
A phase III study indicated that MDMA-assisted therapy represents a potential breakthrough treatment for severe PTSD that merits expedited clinical evaluation. [17] Based on this study, MDMA-assisted psychotherapy was granted breakthrough therapy designation by the FDA, a designation that indicates that there is preliminary evidence that an intervention might offer a substantial improvement ...
Atypical depression is four times more common in females than in males. [7] Individuals with features of atypical depression tend to report an earlier age of onset (e.g., while in high school) of their depressive episodes. These episodes tend to be more chronic than those of major depressive disorder [2] and only have partial remission between ...
While TF-CBT has been shown to be just as effective as Eye movement desensitization and reprocessing (EMDR) for the treatment of chronic post-traumatic stress disorder (PTSD) in adults, the results were tentative given low numbers in the studies, high drop out rates, and high risk of experimenter bias.
Interpersonal therapy is one of the potential effective therapies to treat depressive symptoms in PTSD patients. In clinical studies, interpersonal therapy has led to a decrease in depressive PTSD symptomatology after 16 group sessions. Group sessions follow the same three stages as individual interpersonal therapy.
A 2016 meta-analysis of transcranial direct current stimulation (tDCS) reported some efficacy of tDCS in the treatment of acute depressive disorder with moderate effect size, and low efficacy in treatment-resistant depression, and that use of 2 mA current strength over 20 minutes per day over a short time span can be considered safe. [166]