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The PI3K pathway is a major source of drug resistance in prostate cancer. This is particularly true in castration-resistant prostate cancer, where tumours become resistant to androgen-deprivation therapy, which block the tumours ability to utilise the hormone androgen to grow. [17]
“Prostate cancer is smart—it learns to grow despite this hormone therapy” by tapping into testosterone from other sources in the body. ... Chemo can cause side effects like hair loss, nausea ...
Molecules that cause oxidation in the body are called oxidants. ... With menadione, this problem may be solved due to the nature of prostate cancer cells’ natural deficiency of PI(3)P.
Prostate cancer is the most diagnosed cancer in men in over half of the world's countries, and the leading cause of cancer death in men in around a quarter of countries. [91] Prostate cancer is rare in those under 40 years old, [92] and most cases occur in those over 60 years, [2] with the average person diagnosed at 67. [93]
Additionally, the increased levels of P4 can also cause side effects such as weight gain, fatigue, and mood swings (extreme or rapid changes in mood). [79] In prostate cancer, removal of testicular T through castration (surgical or chemical removal or inactivation of testicles) helps eliminate the growth-promoting effects of androgens. [79]
Most people know that prostate cancer is a disease that affects only men, since the prostate gland is one part of the male genital/urinary system. Shocking statistics aside, prostate cancer is not ...