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Lyme disease, also known as Lyme borreliosis, is a tick-borne disease caused by species of Borrelia bacteria, transmitted by blood-feeding ticks in the genus Ixodes. [4] [9] [10] The most common sign of infection is an expanding red rash, known as erythema migrans (EM), which appears at the site of the tick bite about a week afterwards. [1]
Borrelia afzelii is a species of Borrelia endemic to parts of Eurasia where it is one of the causative agents of Lyme disease.It is transmitted by hard-bodied ticks of the Ixodes genus (Ixodes ricinus in Europe, and Ixodes persulcatus in temperate regions of Asia), infecting various wild mammals in nature.
Patients with Lyme disease who are treated with appropriate antibiotics usually recover rapidly and completely. Antibiotics commonly used include doxycycline, amoxicillin, or cefuroxime axetil. For Anaplasmosis , ehrlichiosis and Rocky Mountain spotted fever, Doxycycline is the first line treatment for adults and children of all ages.
Eight are known to cause Lyme disease or Borreliosis. [6] The major Borrelia species causing Lyme disease are Borrelia burgdorferi, Borrelia afzelii, and Borrelia garinii. [23] All species that cause Lyme disease are referred to collectively as B. burgdorferi sensu lato, [10] while B. burgdorferi itself is specified as B. burgdorferi sensu stricto.
The genomic variations have direct implications on the clinical symptoms of tick-borne Lyme disease. For example, B. burgdorferi s.s.’s tick-borne Lyme disease may manifest with arthritis-like symptoms. [9] In contrast, B. garinii’s tick-borne Lyme disease may cause an infection of the central nervous system. [9]
Borrelia miyamotoi is a bacterium of the spirochete phylum in the genus Borrelia.A zoonotic organism, B. miyamotoi can infect humans through the bite of several species of hard-shell Ixodes ticks, the same kind of ticks that spread B. burgdorferi, the causative bacterium of Lyme disease.
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"Erythema migrans is the only manifestation of Lyme disease in the United States that is sufficiently distinctive to allow clinical diagnosis in the absence of laboratory confirmation." [ 8 ] [ 9 ] Often, but not always, mentions of a target lesion (bull's-eye lesion) are talking about erythema migrans.