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Gastrin is a linear peptide hormone produced by G cells of the duodenum and in the pyloric antrum of the stomach.It is secreted into the bloodstream. The encoded polypeptide is preprogastrin, which is cleaved by enzymes in posttranslational modification to produce progastrin (an intermediate, inactive precursor) and then gastrin in various forms, primarily the following three:
Little gastrin: 2098: 17: Both forms of gastrin are found in the gastric antrum and duodenum: Gastrins stimulate the secretion of gastric acid, pepsinogen, intrinsic factor, and secretin; stimulate intestinal mucosal growth; increase gastric and intestinal motility Big gastrin: 3839: 34: Secretin-glucagon family: Secretin: 3056: 27: Duodenum ...
A G cell or gastrin cell is a type of cell in the stomach and duodenum that secretes gastrin. It works in conjunction with gastric chief cells and parietal cells. G cells are found deep within the pyloric glands of the stomach antrum, and occasionally in the pancreas [1] and duodenum. The vagus nerve innervates the G cells.
Effects on endocrine secretion Effects on exocrine secretion Effects on motility Other effects Stimulus for release; Gastrin: G Cells in stomach ECL cells; parietal cells None Increases acid secretion, increases mucus growth Stimulates gastric contraction None Peptides and amino acids in lumen; gastrin releasing peptide and ACh in nervous reflexes
Progastrin is an 80-amino acid intracellular protein and the precursor of gastrin, a gastrointestinal hormone produced by G cells in the gastric antrum. [1] The main function of gastrin is to regulate acid secretion. [2] During digestion, only gastrin is released into the bloodstream and stimulates the secretion of hydrochloric acid in the ...
Enterochromaffin-like cells or ECL cells are a type of neuroendocrine cell found in the gastric glands of the gastric mucosa beneath the epithelium, in particular in the vicinity of parietal cells, that aid in the production of gastric acid via the release of histamine. They are also considered a type of enteroendocrine cell. [1]
Gastric distention is the enlargement of the stomach, and can be due to a number of causes. [citation needed]Physiologic (normal) gastric distension occurs when eating. . Distension of the upper stomach stimulates the secretion of stomach acid, while distension of the lower stomach stimulates gastrin secret
Gastrin-releasing peptide GRP, is a neuropeptide, a regulatory molecule encoded in the human by the GRP gene. GRP has been implicated in a number of physiological and pathophysiological processes. Most notably, GRP stimulates the release of gastrin from the G cells of the stomach. GRP encodes a number of bombesin-like peptides.