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A summary of CHOP upstream and downstream pathways. The PERK-ATF4-CHOP pathway can induce apoptosis by binding to the death receptors and upregulating the expression of death receptor 4 (DR4) and DR5. CHOP also interacts with the phosphorylated transcription factor JUN to form a complex that binds to the promoter region of DR4 in lung cancer ...
Rescue treatment involves acute symptomatic control with medication. [4] Recommendations for rescue therapy of migraine include: (1) migraine-specific agents such as triptans, CGRP antagonists, or ditans for patients with severe headaches or for headaches that respond poorly to analgesics, (2) non-oral (typically nasal or injection) route of administration for patients with vomiting, (3) avoid ...
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This page was last edited on 13 August 2016, at 15:08 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may ...
The ICHD-1 referred to this as menstrual migraine, noting that there were no strict guidelines for this diagnosis, but that at least 90% of a woman's attacks should occur within two days of the beginning or end of menstruation. When the ICHD-2 was published, explicit guidelines for a diagnosis of two distinct types of menstruation-related ...
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On the other hand, ATF4 and CHOP work together to induce cell death, as well as regulating amino acid biosynthesis, transport and metabolic processes. The presence of a leucine zipper domain ( bZIP ) allows ATF4 to work together with many other proteins, thus creating specific responses to different types of stressors.
Each article at WikiPathways is dedicated to a particular pathway. Many types of molecular pathways are covered, including metabolic, [7] signaling, regulatory, etc. and the supported [8] species include human, mouse, zebrafish, fruit fly, C. elegans, yeast, rice and arabidopsis, [9] as well as bacteria and plant species.