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The Total effective dose equivalent (TEDE) is a radiation dosimetry quantity defined by the US Nuclear Regulatory Commission to monitor and control human exposure to ionizing radiation. It is defined differently in the NRC regulations and NRC glossary.
Effective dose is a dose quantity in the International Commission on Radiological Protection (ICRP) system of radiological protection. [1]It is the tissue-weighted sum of the equivalent doses in all specified tissues and organs of the human body and represents the stochastic health risk to the whole body, which is the probability of cancer induction and genetic effects, of low levels of ...
This dose-response model is known as 'linear-non-threshold' or LNT. To see the model, please see dashed line in the graph "Dose response curve of linear-non-threshold model". Because of this uncertainty at low doses, the Commission does not calculate the hypothetical number of cancer cases. [5]
Equivalent dose is designated by the ICRP as a "limiting quantity"; to specify exposure limits to ensure that "the occurrence of stochastic health effects is kept below unacceptable levels and that tissue reactions are avoided".
The AUC (from zero to infinity) represents the total drug exposure across time.AUC is a useful metric when trying to determine whether two formulations of the same dose (for example a capsule and a tablet) result in equal amounts of tissue or plasma exposure.
The effective dose E is designed to account for this variation by the application of specific weighting factors for each tissue (W T). Effective dose provides the equivalent whole body dose that gives the same risk as the localised exposure.
CDE is defined by the United States Nuclear Regulatory Commission in Title 10, Section 20.1003, of the Code of Federal Regulations (10 CFR 20.1003), such that "The Committed dose equivalent, CDE (H T,50) is the dose to some specific organ or tissue of reference (T) that will be received from an intake of radioactive material by an individual during the 50-year period following the intake".
Absorbed dose is a dose quantity which is the measure of the energy deposited in matter by ionizing radiation per unit mass.Absorbed dose is used in the calculation of dose uptake in living tissue in both radiation protection (reduction of harmful effects), and radiology (potential beneficial effects, for example in cancer treatment).