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Bebtelovimab is a neutralizing human immunoglobulin G1 (IgG1) monoclonal antibody, isolated from a patient who has recovered from the Coronavirus disease 2019 (COVID-19), directed against the spike (S) protein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that can potentially be used for immunization against COVID-19. [6]
A benefit of casirivimab and imdevimab treatment has not been shown in people hospitalized due to COVID‑19. [9] Monoclonal antibodies, such as casirivimab and imdevimab, may be associated with worse clinical outcomes when administered to hospitalized people with COVID‑19 requiring high flow oxygen or mechanical ventilation. [9]
Sotrovimab, sold under the brand name Xevudy, is a human neutralizing monoclonal antibody with activity against severe acute respiratory syndrome coronavirus 2, known as SARS-CoV-2. [10] [12] [13] It was developed by GlaxoSmithKline and Vir Biotechnology, Inc. [12] [14] Sotrovimab is designed to attach to the spike protein of SARS-CoV-2. [12 ...
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Monoclonal antibodies are no longer available to treat Covid in the U.S. after the FDA rescinded its authorization of the last one standing, bebtelovimab.
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